Dr. Rini on Axitinib for Treatment of Metastatic Renal Cell Carcinoma
What Is Axitinib?
Axitinib interferes with the growth of some cancer cells.
Axitinib is used to treat advanced kidney cancer.
Axitinib is usually given after other treatments have failed.
Axitinib may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not use axitinib if you are allergic to it.
Tell your doctor if you have ever had:
- a perforation (a hole or tear) in your stomach or intestines;
- bleeding problems, or a wound that has not healed;
- a heart attack, heart failure, stroke, or blood clot.
- high blood pressure;
- liver disease; or
- a thyroid disorder.
You may need to have a negative pregnancy test before starting this treatment.
Both men and women using this medicine should use effective birth control to prevent pregnancy.Axitinib can cause harm an unborn baby if the mother or father is using this medicine.
Keep using birth control for at least 1 week after your last dose.Tell your doctor right away if a pregnancy occurs while either the mother or the father is using axitinib.
This medicine may affect fertility (ability to have children) in both men and women. However,it is important to use birth control to prevent pregnancy because axitinib can harm an unborn baby.
It is not safe to breast-feed a baby while you are using this medicine.Also do not breast-feed for at least 2 weeks after your last dose.
Axitinib Side Effects
Get emergency medical help if you havesigns of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some people taking axitinib have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines.Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Also call your doctor at once if you have:
- chest pain or pressure, pain spreading to your jaw or shoulder, trouble breathing;
- sudden numbness or weakness, problems with vision or speech;
- headache, confusion, thinking problems, seizure (convulsions);
- a light-headed feeling, like you might pass out;
- easy bruising, unusual bleeding, purple or red spots under your skin;
- heavy menstrual bleeding;
- any bleeding that will not stop;
- pink or brown urine;
- heart problems--swelling, rapid weight gain, feeling short of breath;
- signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
- signs of a thyroid problem--sudden weight gain or loss, feeling very weak or tired, muscle pain, feeling hot or cold, hair loss, hoarse or deepened voice.
Common side effects may include:
- nausea, vomiting, diarrhea, constipation;
- rash, itching, redness, and peeling skin on your hands or feet;
- feeling weak or tired;
- increased blood pressure;
- decreased appetite, weight loss; or
- hoarse voice.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Grapefruit may interact with axitinib and lead to unwanted side effects.Avoid the use of grapefruit products.
This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Sometimes it is not safe to use certain medications at the same time.Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may affect axitinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Axitinib should be taken at evenly spaced intervals, usually once every 12 hours.
Take this medicine with a full glass of water. You may take axitinib with or without food.
Swallow the tablet whole and do not crush, chew, or break it.
If you vomit shortly after taking axitinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
Your blood pressure will need to be checked often. You may also need frequent medical tests.
If you need surgery, tell your surgeon you currently use axitinib.You will need to stop using the medicine at least 24 hours before a planned surgery.
Store at room temperature away from moisture and heat.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Skip the missed dose and use your next dose at the regular time.Do notuse two doses at one time.
Copyright 1996-2019 Cerner Multum, Inc.
Video: Axitinib IS the New Standard of Care in 2nd-line: PRO Brian I. Rini, M.D.
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